Presentation of the research “Non-Invasive Treatment of Feline Mammary Adenocarcinoma Using Irreversible Electroporation” at the National and International Veterinary Students Congress

The study entitled “Non-Invasive Treatment of Feline Mammary Adenocarcinoma Using Irreversible Electroporation”, conducted through a collaboration between Pars Tarava Company and Novin Pet Clinic in Tehran, was presented as a scientific poster at the 13th National and 1st International Veterinary Students Congress of Iran, held at the University of Tehran from 19 to 21 Azar 1404 (10–12 December 2025).

In this research, we investigated a novel, non-invasive, and safe approach for the treatment of feline mammary adenocarcinoma using Irreversible Electroporation (IRE) technology. Mammary tumors are among the most common and aggressive neoplasms in domestic cats, and in many cases, surgical intervention poses serious challenges due to the high risks associated with anesthesia or other therapeutic limitations.

In this study, a two-year-old Persian cat with a history of repeated anesthesia and respiratory complications was treated with IRE over two sessions without the use of general anesthesia. The treatment protocol employed an electric field strength of 50 V/cm using a Pars Tarava irreversible electroporation device. A plate electrode was applied non-invasively over the tumor with the aid of ultrasound gel to ensure uniform electric field coverage.

Clinical evaluation and ultrasonographic imaging demonstrated that the tumor, initially measuring 3 × 3 cm, decreased to 2 × 2.5 cm sixteen days after the first treatment session. One month after the second session, the tumor diameter was reduced to 0.72 cm, corresponding to an overall tumor volume reduction of approximately 98.6%. Throughout the treatment period, no side effects, pain, inflammation, or metastasis were observed, and the tumor tissue gradually transformed from a soft consistency to a dense, fibrotic structure. The diagnosis of mammary adenocarcinoma was confirmed through histopathological examination.

Furthermore, simulation of the electric field distribution using COMSOL software demonstrated uniform field coverage within the tumor while sparing the surrounding healthy tissues from damage.

This scientific presentation highlights the safety and efficacy of Irreversible Electroporation as a non-invasive therapeutic modality for the treatment of mammary tumors in veterinary medicine and supports the further development of its clinical applications in animal oncology, particularly in cases where anesthesia or surgery carries a high risk.

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